I have a similar problem with my system. I'm running Vista, SEP (licensed through my employer), and the Plus version of Ad-Aware (bought from an online reseller). All three products worked together flawlessly until I upgraded to Ad-Aware 2008. The 2008 version will not pass "scanning active processes" and can then only be closed with task manager. I've reinstalled 2007, which works, but a full system scan now takes about 9-10 hours (2 physical hard drives, 320 GB each, one of which is partitioned into 2 drives). IIRC, the initial issue I experienced with 2008 was that it couldn't download or couldn't load a definitions file that came out around the time of the initial post in this thread.